AirHint found the following cheapest return flights from Madrid (MAD) to Santiago (SCL) in April 2026 (see full year).

Return flights

23 Apr - 18 May	Avianca
22 Apr - 18 May	Avianca
20 Apr - 18 May	Avianca
24 Apr - 27 May	Delta
24 Apr - 27 May	Iberia	direct
29 Apr - 24 May	Iberia	direct
27 Apr - 25 May	Iberia	direct
02 Apr - 26 Apr	Delta
06 Apr - 26 Apr	Delta
01 Apr - 26 Apr	Delta
03 Apr - 26 Apr	Delta
28 Apr - 27 May	LATAM Airlines Group	direct
24 Apr - 19 May	Iberia	direct
29 Apr - 31 May	LATAM Airlines Group
19 Apr - 26 Apr	Delta
16 Apr - 25 Apr	Plus Ultra Lineas Aereas
06 Apr - 21 Apr	Delta
14 Apr - 27 Apr	Delta
02 Apr - 21 Apr	Delta
01 Apr - 29 Apr	Avianca

Also check the deals for one-way flights from Madrid to Santiago in April.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santiago in April from 695€

Return flights