Cheapest one-way flights from Madrid to Santiago in April from 355€

Best time to book flights for Madrid (MAD) to Santiago (SCL) flights at AirHint

AirHint found the following cheapest one-way flights from Madrid (MAD) to Santiago (SCL) in April 2025 (see full year).

One-Way flights

07 Apr LATAM Airlines Group direct
08 Apr LATAM Airlines Group direct
17 Apr LATAM Airlines Group
17 Apr LATAM Airlines Group direct
16 Apr LATAM Airlines Group direct
19 Apr LATAM Airlines Group direct
01 Apr LATAM Airlines Group direct
28 Apr LATAM Airlines Group direct
05 Apr LATAM Airlines Group direct
22 Apr LATAM Airlines Group direct

Also check the deals for return flights from Madrid to Santiago in April.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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