Cheapest one-way flights from Madrid to Santiago in April from 415€

AirHint found the following cheapest one-way flights from Madrid (MAD) to Santiago (SCL) in April 2026 (see full year).

One-Way flights

10 Apr Iberia
14 Apr Iberia
15 Apr Iberia
01 Apr Avianca
16 Apr Avianca
04 Apr Avianca
20 Apr LATAM Airlines Group direct
01 Apr LATAM Airlines Group direct
16 Apr LATAM Airlines Group direct
10 Apr LATAM Airlines Group direct

Also check the deals for return flights from Madrid to Santiago in April.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santiago

Cheap car rent in Santiago

Feel free to contact us with any feedback or request another flight research.