Cheapest one-way flights from Madrid to Santiago in April from 410€

AirHint found the following cheapest one-way flights from Madrid (MAD) to Santiago (SCL) in April 2026 (see full year).

One-Way flights

15 Apr LATAM Airlines Group
09 Apr LATAM Airlines Group
14 Apr Azul Airlines
28 Apr LATAM Airlines Group
04 Apr LATAM Airlines Group direct
08 Apr LATAM Airlines Group
17 Apr Avianca
30 Apr Avianca
18 Apr Avianca
20 Apr Avianca

Also check the deals for return flights from Madrid to Santiago in April.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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