AirHint found the following cheapest return flights from Madrid (MAD) to Santiago (SCL) in December 2025 (see full year).

Return flights

01 Dec - 31 Jan	Air Canada
18 Dec - 24 Jan	Air Canada
09 Dec - 13 Jan	Air Canada
18 Dec - 19 Jan	Air Canada
05 Dec - 26 Dec	Delta
29 Dec - 27 Jan	Air Canada
03 Dec - 08 Dec	Delta
07 Dec - 29 Jan	Delta
17 Dec - 16 Jan	Air Canada
28 Dec - 15 Jan	Delta
25 Dec - 15 Jan	Delta
06 Dec - 26 Dec	Delta
31 Dec - 29 Jan	Delta
23 Dec - 29 Dec	Delta
03 Dec - 11 Dec	Avianca
03 Dec - 11 Dec	Iberia	direct
03 Dec - 14 Dec	LATAM Airlines Group
06 Dec - 14 Dec	LATAM Airlines Group
05 Dec - 12 Dec	Iberia	direct
05 Dec - 14 Dec	LATAM Airlines Group

Also check the deals for one-way flights from Madrid to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santiago in December from 699€

Return flights