AirHint found the following cheapest return flights from Madrid (MAD) to Santiago (SCL) in December 2025 (see full year).

Return flights

24 Dec - 22 Jan	Delta
24 Dec - 26 Jan	Delta
26 Dec - 22 Jan	Delta
26 Dec - 27 Jan	Delta
29 Dec - 28 Jan	Delta
29 Dec - 29 Jan	Delta
29 Dec - 27 Jan	Delta
29 Dec - 21 Jan	Delta
29 Dec - 26 Jan	Delta
24 Dec - 21 Jan	Delta
26 Dec - 27 Dec	Delta
24 Dec - 26 Dec	Delta
24 Dec - 27 Dec	Delta
25 Dec - 30 Dec	Delta
23 Dec - 27 Dec	Delta
24 Dec - 31 Dec	Iberia	direct
26 Dec - 30 Dec	Delta
27 Dec - 30 Dec	Delta
27 Dec - 28 Dec	Delta
26 Dec - 30 Dec	Iberia	direct

Also check the deals for one-way flights from Madrid to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santiago in December from 700€

Return flights