AirHint found the following cheapest return flights from Madrid (MAD) to Santiago (SCL) in December 2025 (see full year).

Return flights

08 Dec - 29 Jan	Delta
10 Dec - 29 Jan	Delta
06 Dec - 22 Jan	Delta
08 Dec - 22 Jan	Delta
02 Dec - 09 Dec	LATAM Airlines Group	direct
01 Dec - 08 Dec	LATAM Airlines Group
01 Dec - 09 Dec	LATAM Airlines Group
03 Dec - 13 Dec	Iberia
08 Dec - 15 Dec	Iberia
03 Dec - 15 Dec	Iberia
01 Dec - 12 Dec	Iberia
09 Dec - 25 Jan	Delta
10 Dec - 25 Jan	Delta
10 Dec - 24 Jan	Delta
07 Dec - 20 Dec	Iberia
05 Dec - 22 Dec	Iberia
05 Dec - 16 Dec	Iberia	direct
26 Dec - 27 Jan	Iberia	direct
09 Dec - 25 Jan	Iberia	direct
03 Dec - 21 Jan	Delta

Also check the deals for one-way flights from Madrid to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santiago in December from 699€

Return flights