AirHint found the following cheapest return flights from Madrid (MAD) to Santiago (SCL) in December 2025 (see full year).

Return flights

01 Dec - 08 Dec	Delta
03 Dec - 22 Dec	Delta
03 Dec - 26 Dec	Delta
09 Dec - 15 Jan	Delta
10 Dec - 27 Jan	Delta
06 Dec - 08 Dec	Delta
01 Dec - 22 Dec	Delta
31 Dec - 15 Jan	Delta
29 Dec - 15 Jan	Delta
29 Dec - 18 Jan	Delta
01 Dec - 09 Dec	Delta
08 Dec - 29 Dec	Delta
27 Dec - 26 Jan	Delta
09 Dec - 13 Jan	Delta
25 Dec - 16 Jan	Air Canada
25 Dec - 18 Jan	Air Canada
25 Dec - 17 Jan	Air Canada
01 Dec - 29 Dec	Delta
02 Dec - 09 Dec	Avianca
04 Dec - 13 Dec	Iberia

Also check the deals for one-way flights from Madrid to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santiago in December from 729€

Return flights