AirHint found the following cheapest return flights from Madrid (MAD) to Santiago (SCL) in December 2025 (see full year).

Return flights

10 Dec - 29 Jan	Delta
08 Dec - 29 Jan	Delta
03 Dec - 09 Dec	Delta
05 Dec - 22 Jan	Delta
08 Dec - 22 Jan	Delta
05 Dec - 08 Dec	Delta
05 Dec - 09 Dec	Delta
23 Dec - 27 Jan	Delta
01 Dec - 08 Dec	ITA Airways
02 Dec - 09 Dec	SWISS
10 Dec - 28 Dec	Delta
10 Dec - 27 Dec	Delta
07 Dec - 27 Dec	Delta
05 Dec - 28 Dec	Delta
08 Dec - 28 Dec	Delta
07 Dec - 24 Jan	Delta
05 Dec - 24 Jan	Delta
25 Dec - 21 Jan	Delta
24 Dec - 26 Jan	Delta
24 Dec - 29 Jan	Delta

Also check the deals for one-way flights from Madrid to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santiago in December from 701€

Return flights