Cheapest one-way flights from Madrid to Santiago in December from 432€

AirHint found the following cheapest one-way flights from Madrid (MAD) to Santiago (SCL) in December 2025 (see full year).

One-Way flights

07 Dec Azul Airlines
02 Dec Azul Airlines
06 Dec Azul Airlines
30 Dec Azul Airlines
31 Dec Azul Airlines
07 Dec LATAM Airlines Group direct
08 Dec Ryanair
15 Dec Air Canada
06 Dec LATAM Airlines Group direct
10 Dec Azul Airlines

Also check the deals for return flights from Madrid to Santiago in December.

Powered by

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santiago

Cheap car rent in Santiago

Feel free to contact us with any feedback or request another flight research.