Cheapest one-way flights from Madrid to Santiago in December from 506€

AirHint found the following cheapest one-way flights from Madrid (MAD) to Santiago (SCL) in December 2025 (see full year).

One-Way flights

30 Dec LATAM Airlines Group direct
25 Dec Air Canada
31 Dec LATAM Airlines Group
25 Dec Iberia direct
31 Dec Iberia direct
24 Dec Iberia direct
26 Dec Iberia direct
23 Dec Iberia direct
22 Dec Iberia direct
21 Dec Iberia direct

Also check the deals for return flights from Madrid to Santiago in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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