Cheapest one-way flights from Madrid to Santiago in December from 483€

Best time to book flights for Madrid (MAD) to Santiago (SCL) flights at AirHint

AirHint found the following cheapest one-way flights from Madrid (MAD) to Santiago (SCL) in December 2025 (see full year).

One-Way flights

04 Dec Avianca
03 Dec Avianca
11 Dec Ryanair
15 Dec Ryanair
12 Dec Plus Ultra Lineas Aereas
26 Dec Plus Ultra Lineas Aereas
24 Dec Plus Ultra Lineas Aereas
25 Dec Plus Ultra Lineas Aereas
13 Dec Air Europa
17 Dec Air Europa

Also check the deals for return flights from Madrid to Santiago in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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