Cheapest one-way flights from Madrid to Santiago in December from 409€

AirHint found the following cheapest one-way flights from Madrid (MAD) to Santiago (SCL) in December 2025 (see full year).

One-Way flights

02 Dec Azul Airlines
06 Dec Azul Airlines
07 Dec Azul Airlines
29 Dec LATAM Airlines Group direct
01 Dec Azul Airlines
31 Dec Iberia
05 Dec Air Canada
07 Dec LATAM Airlines Group direct
27 Dec Air Canada
05 Dec LATAM Airlines Group direct

Also check the deals for return flights from Madrid to Santiago in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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