AirHint found the following cheapest return flights from Madrid (MAD) to Rio Negro (MDE) in September 2025 (see full year).

Return flights

29 Sep - 17 Oct	WORLD2FLY
06 Sep - 21 Sep	Air Europa
10 Sep - 01 Oct	Air Europa
20 Sep - 27 Sep	WORLD2FLY
29 Sep - 08 Oct	WORLD2FLY
22 Sep - 15 Oct	Avianca	direct
06 Sep - 13 Sep	Ryanair
14 Sep - 19 Oct	Avianca	direct
24 Sep - 15 Oct	Avianca	direct
24 Sep - 20 Oct	Avianca	direct
03 Sep - 17 Sep	Air Europa
24 Sep - 08 Oct	Air Europa
27 Sep - 18 Oct	Plus Ultra Lineas Aereas
12 Sep - 17 Oct	TAP
22 Sep - 27 Sep	Ryanair
11 Sep - 26 Sep	TAP
09 Sep - 24 Sep	Ryanair
12 Sep - 28 Sep	TAP
04 Sep - 22 Sep	Air Europa
05 Sep - 22 Sep	Air Europa

Also check the deals for one-way flights from Madrid to Rio Negro in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Rio Negro in September from 596€

Return flights