AirHint found the following cheapest return flights from Madrid (MAD) to Rio Negro (MDE) in October 2025 (see full year).

Return flights

01 Oct - 19 Oct	Plus Ultra Lineas Aereas
06 Oct - 15 Oct	Ryanair
08 Oct - 22 Oct	Air Europa
06 Oct - 18 Oct	Ryanair
06 Oct - 12 Oct	Ryanair
31 Oct - 10 Nov	Air Europa
31 Oct - 19 Nov	Air Europa
22 Oct - 31 Oct	Air Europa
12 Oct - 26 Oct	Air Europa
06 Oct - 16 Oct	Ryanair
06 Oct - 17 Oct	Ryanair
10 Oct - 31 Oct	Air Europa
06 Oct - 03 Nov	Ryanair
06 Oct - 28 Nov	Ryanair
21 Oct - 10 Nov	Avianca
01 Oct - 17 Nov	Iberia
18 Oct - 02 Nov	Avianca
24 Oct - 12 Nov	TAP
31 Oct - 03 Nov	Avianca	direct
31 Oct - 10 Nov	Avianca	direct

Also check the deals for one-way flights from Madrid to Rio Negro in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Rio Negro in October from 653€

Return flights