AirHint found the following cheapest return flights from Madrid (MAD) to Guayaquil (GYE) in September 2025 (see full year).

Return flights

26 Sep - 28 Sep	Avianca
12 Sep - 27 Sep	Avianca
26 Sep - 17 Oct	Avianca
11 Sep - 26 Sep	Avianca
13 Sep - 29 Sep	Avianca
12 Sep - 28 Sep	Avianca
08 Sep - 22 Sep	Avianca
10 Sep - 23 Sep	Avianca
26 Sep - 21 Oct	Avianca
25 Sep - 16 Oct	Avianca
04 Sep - 20 Sep	Avianca
02 Sep - 30 Sep	Avianca
01 Sep - 30 Sep	Avianca
23 Sep - 11 Oct	Avianca
23 Sep - 08 Oct	Avianca
29 Sep - 31 Oct	Avianca
05 Sep - 05 Oct	Avianca
01 Sep - 01 Oct	Avianca
30 Sep - 15 Oct	Avianca
05 Sep - 05 Oct	Iberia	direct

Also check the deals for one-way flights from Madrid to Guayaquil in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Guayaquil in September from 663€

Return flights