AirHint found the following cheapest return flights from Madrid (MAD) to Guayaquil (GYE) in December 2025 (see full year).

Return flights

28 Dec - 25 Jan	Air Europa
29 Dec - 27 Jan	Ryanair
28 Dec - 28 Jan	Air Europa
29 Dec - 26 Jan	Ryanair
29 Dec - 19 Jan	Ryanair
28 Dec - 17 Jan	Air Europa
31 Dec - 28 Jan	TAP
30 Dec - 30 Jan	Air Europa
31 Dec - 27 Jan	TAP
24 Dec - 20 Jan	TAP
24 Dec - 30 Dec	TAP
24 Dec - 31 Dec	TAP
24 Dec - 26 Dec	LATAM Airlines Group
22 Dec - 29 Dec	TAP
23 Dec - 30 Dec	TAP
21 Dec - 29 Dec	Royal Air Maroc
24 Dec - 31 Dec	Iberia	direct
24 Dec - 26 Dec	Iberia	direct
22 Dec - 29 Dec	Iberia	direct
21 Dec - 28 Dec	Royal Air Maroc

Also check the deals for one-way flights from Madrid to Guayaquil in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Guayaquil

Cheap car rent in Guayaquil

Cheapest return flights from Madrid to Guayaquil in December from 900€

Return flights