AirHint found the following cheapest return flights from Madrid (MAD) to Guayaquil (GYE) in October 2025 (see full year).

Return flights

22 Oct - 12 Nov	Avianca
19 Oct - 22 Oct	Avianca
23 Oct - 04 Nov	Avianca
29 Oct - 05 Nov	Iberia	direct
22 Oct - 12 Nov	Iberia	direct
09 Oct - 19 Oct	Avianca
18 Oct - 31 Oct	Avianca
18 Oct - 30 Oct	Avianca
02 Oct - 24 Oct	Avianca
10 Oct - 26 Oct	Avianca
01 Oct - 15 Oct	Avianca
04 Oct - 18 Oct	Avianca
06 Oct - 12 Oct	Avianca
01 Oct - 31 Oct	Avianca
05 Oct - 09 Nov	Avianca
06 Oct - 10 Nov	Avianca
16 Oct - 03 Nov	Avianca
15 Oct - 02 Nov	Avianca
15 Oct - 02 Nov	Air Europa	direct
05 Oct - 09 Nov	Air Europa	direct

Also check the deals for one-way flights from Madrid to Guayaquil in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Guayaquil in October from 666€

Return flights