AirHint found the following cheapest return flights from Madrid (MAD) to Guayaquil (GYE) in October 2025 (see full year).

Return flights

30 Oct - 24 Nov	Avianca
19 Oct - 17 Nov	Avianca
19 Oct - 16 Nov	Avianca
30 Oct - 03 Nov	Avianca
30 Oct - 06 Nov	Avianca
29 Oct - 10 Nov	Avianca
30 Oct - 09 Nov	Avianca
27 Oct - 05 Nov	Avianca
27 Oct - 09 Nov	Avianca
27 Oct - 24 Nov	Avianca
15 Oct - 21 Oct	KLM
21 Oct - 28 Oct	Avianca
19 Oct - 27 Oct	Avianca
24 Oct - 28 Oct	Avianca
16 Oct - 27 Oct	Avianca
21 Oct - 29 Oct	Avianca
19 Oct - 24 Oct	Avianca
20 Oct - 24 Oct	Avianca
18 Oct - 27 Oct	Iberia
22 Oct - 26 Oct	Avianca

Also check the deals for one-way flights from Madrid to Guayaquil in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Guayaquil in October from 718€

Return flights