AirHint found the following cheapest return flights from Madrid (MAD) to Sao Paulo (GRU) in September 2025 (see full year).

Return flights

14 Sep - 28 Sep	Iberia	direct
10 Sep - 20 Oct	Avianca
14 Sep - 29 Sep	Iberia	direct
11 Sep - 24 Sep	TAP
10 Sep - 24 Sep	TAP
17 Sep - 01 Oct	TAP
14 Sep - 22 Sep	Iberia
08 Sep - 24 Sep	TAP
11 Sep - 25 Sep	Avianca
11 Sep - 24 Sep	Iberia	direct
12 Sep - 28 Sep	Iberia	direct
14 Sep - 14 Oct	LATAM Airlines Group	direct
03 Sep - 24 Sep	TAP
15 Sep - 16 Oct	TAP
24 Sep - 08 Oct	Avianca
26 Sep - 28 Oct	Delta
25 Sep - 13 Oct	Avianca
25 Sep - 16 Oct	Avianca
28 Sep - 14 Oct	Delta
24 Sep - 01 Oct	Delta

Also check the deals for one-way flights from Madrid to Sao Paulo in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Sao Paulo in September from 533€

Return flights