AirHint found the following cheapest return flights from Madrid (MAD) to Sao Paulo (GRU) in September 2025 (see full year).

Return flights

17 Sep - 27 Oct	TAP
01 Sep - 31 Oct	Avianca
08 Sep - 18 Oct	TAP
19 Sep - 14 Oct	TAP
11 Sep - 05 Oct	Avianca
01 Sep - 31 Oct	LATAM Airlines Group	direct
08 Sep - 18 Oct	LATAM Airlines Group	direct
15 Sep - 28 Sep	Delta
15 Sep - 21 Sep	Delta
08 Sep - 21 Sep	Delta
03 Sep - 28 Sep	Delta
04 Sep - 28 Sep	Delta
11 Sep - 21 Sep	Delta
08 Sep - 24 Sep	Delta
18 Sep - 28 Sep	Delta
10 Sep - 24 Sep	Delta
09 Sep - 24 Sep	Delta
23 Sep - 07 Oct	Delta
10 Sep - 07 Oct	Delta
18 Sep - 05 Oct	Delta

Also check the deals for one-way flights from Madrid to Sao Paulo in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Sao Paulo in September from 529€

Return flights