AirHint found the following cheapest return flights from Madrid (MAD) to Sao Paulo (GRU) in December 2025 (see full year).

Return flights

02 Dec - 09 Dec	ITA Airways
01 Dec - 06 Dec	TAP
01 Dec - 08 Dec	TAP
04 Dec - 08 Dec	TAP
02 Dec - 08 Dec	TAP
01 Dec - 09 Dec	TAP
05 Dec - 09 Dec	TAP
02 Dec - 10 Dec	ITA Airways
31 Dec - 31 Jan	TAP
24 Dec - 22 Jan	TAP
08 Dec - 08 Dec	ITA Airways
08 Dec - 31 Jan	Iberia	direct
09 Dec - 31 Jan	Iberia	direct
05 Dec - 14 Dec	Iberia	direct
04 Dec - 31 Jan	TAP
29 Dec - 22 Jan	LATAM Airlines Group
08 Dec - 30 Jan	Delta
08 Dec - 30 Jan	Iberia	direct
09 Dec - 30 Jan	Iberia	direct
26 Dec - 28 Jan	Air Europa	direct

Also check the deals for one-way flights from Madrid to Sao Paulo in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Sao Paulo in December from 640€

Return flights