AirHint found the following cheapest return flights from Madrid (MAD) to Sao Paulo (GRU) in December 2025 (see full year).

Return flights

02 Dec - 09 Dec	Royal Air Maroc
01 Dec - 10 Dec	Royal Air Maroc
02 Dec - 12 Dec	Royal Air Maroc
01 Dec - 09 Dec	Royal Air Maroc
01 Dec - 07 Dec	Royal Air Maroc
02 Dec - 10 Dec	Royal Air Maroc
05 Dec - 12 Dec	Royal Air Maroc
01 Dec - 28 Jan	Royal Air Maroc
01 Dec - 08 Dec	TAP
01 Dec - 31 Dec	Royal Air Maroc
31 Dec - 24 Jan	Delta
31 Dec - 23 Jan	Delta
08 Dec - 23 Jan	Royal Air Maroc
05 Dec - 08 Dec	Air Canada
25 Dec - 28 Jan	Delta
25 Dec - 27 Jan	Delta
25 Dec - 26 Jan	Delta
27 Dec - 28 Jan	Iberia
29 Dec - 29 Jan	TAP
02 Dec - 02 Jan	Royal Air Maroc

Also check the deals for one-way flights from Madrid to Sao Paulo in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Sao Paulo in December from 550€

Return flights