AirHint found the following cheapest return flights from Madrid (MAD) to Asuncion (ASU) in October 2025 (see full year).

Return flights

27 Oct - 19 Nov	Air Europa	direct
28 Oct - 11 Nov	Air Europa	direct
09 Oct - 24 Oct	Avianca
21 Oct - 04 Nov	Avianca
24 Oct - 22 Nov	LATAM Airlines Group
29 Oct - 29 Nov	Avianca
20 Oct - 27 Oct	Air Europa	direct
29 Oct - 29 Nov	Air Europa	direct
24 Oct - 22 Nov	Air Europa	direct
09 Oct - 23 Oct	Avianca
02 Oct - 28 Oct	Avianca
02 Oct - 16 Oct	LATAM Airlines Group
13 Oct - 26 Oct	Air Europa	direct
07 Oct - 31 Oct	TAP
16 Oct - 26 Oct	Avianca
15 Oct - 14 Nov	Iberia
20 Oct - 09 Nov	TAP
17 Oct - 31 Oct	Iberia
28 Oct - 25 Nov	Iberia
13 Oct - 17 Oct	TAP

Also check the deals for one-way flights from Madrid to Asuncion in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Asuncion in October from 844€

Return flights