AirHint found the following cheapest return flights from La Serena (LSC) to Antofagasta (ANF) in October 2025 (see full year).

Return flights

12 Oct - 15 Oct	JetSmart	direct
12 Oct - 21 Oct	JetSmart	direct
20 Oct - 21 Oct	JetSmart	direct
08 Oct - 15 Oct	JetSmart	direct
08 Oct - 21 Oct	JetSmart	direct
05 Oct - 15 Oct	JetSmart	direct
05 Oct - 21 Oct	JetSmart	direct
15 Oct - 21 Oct	JetSmart	direct
12 Oct - 17 Oct	JetSmart	direct
19 Oct - 21 Oct	JetSmart	direct

Also check the deals for one-way flights from La Serena to Antofagasta in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from La Serena to Antofagasta in October from 33€

Return flights