AirHint found the following cheapest return flights from London (LON) to Santiago (SCL) in October 2025 (see full year).

Return flights

07 Oct - 07 Nov	Vueling Airlines
30 Oct - 11 Nov	Vueling Airlines
30 Oct - 13 Nov	Vueling Airlines
30 Oct - 22 Nov	Vueling Airlines
02 Oct - 20 Oct	Vueling Airlines
06 Oct - 12 Oct	Air France
29 Oct - 04 Nov	Wizz Air UK
14 Oct - 17 Oct	Vueling Airlines
19 Oct - 26 Oct	Ryanair
08 Oct - 13 Oct	Virgin Atlantic
14 Oct - 21 Oct	Vueling Airlines
27 Oct - 13 Nov	TAP
25 Oct - 02 Nov	Lufthansa
16 Oct - 23 Oct	Avianca
02 Oct - 09 Oct	Vueling Airlines
02 Oct - 07 Oct	Avianca
22 Oct - 09 Nov	Avianca
23 Oct - 14 Nov	Ryanair
26 Oct - 13 Nov	Avianca
06 Oct - 21 Oct	Avianca

Also check the deals for one-way flights from London to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from London to Santiago in October from 755€

Return flights