AirHint found the following cheapest return flights from Lisbon (LIS) to Santiago (SCL) in December 2025 (see full year).

Return flights

05 Dec - 10 Dec	KLM
01 Dec - 08 Dec	Azores Airlines
03 Dec - 10 Dec	KLM
02 Dec - 09 Dec	Iberia
03 Dec - 20 Jan	Ryanair
25 Dec - 27 Jan	LATAM Airlines Group
31 Dec - 30 Jan	Air Europa
30 Dec - 23 Jan	LATAM Airlines Group
03 Dec - 19 Jan	Ryanair
23 Dec - 27 Jan	Royal Air Maroc
02 Dec - 20 Jan	Azores Airlines
04 Dec - 24 Dec	Ryanair
30 Dec - 12 Jan	LATAM Airlines Group
26 Dec - 14 Jan	Ryanair
02 Dec - 11 Dec	Iberia
28 Dec - 11 Jan	Ryanair
13 Dec - 15 Dec	LATAM Airlines Group
23 Dec - 30 Dec	Air Canada
12 Dec - 28 Dec	LATAM Airlines Group
22 Dec - 30 Dec	LATAM Airlines Group

Also check the deals for one-way flights from Lisbon to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Lisbon to Santiago in December from 880€

Return flights