AirHint found the following cheapest return flights from Lisbon (LIS) to Prague (PRG) in September 2025 (see full year).

Return flights

23 Sep - 30 Sep	Wizz Air Malta
17 Sep - 30 Sep	easyJet
23 Sep - 24 Sep	Wizz Air Malta
16 Sep - 17 Sep	easyJet
24 Sep - 30 Sep	easyJet
16 Sep - 30 Sep	easyJet
24 Sep - 29 Sep	Air Europa
29 Sep - 04 Oct	Ryanair
15 Sep - 30 Sep	easyJet
15 Sep - 23 Sep	Ryanair
15 Sep - 17 Sep	Ryanair
24 Sep - 01 Oct	easyJet
30 Sep - 06 Oct	TAP
30 Sep - 05 Oct	TAP
24 Sep - 05 Oct	easyJet
17 Sep - 01 Oct	Wizz Air
16 Sep - 08 Oct	easyJet
16 Sep - 09 Oct	easyJet
28 Sep - 04 Oct	Ryanair
27 Sep - 01 Oct	Wizz Air Malta

Also check the deals for one-way flights from Lisbon to Prague in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Lisbon to Prague in September from 161€

Return flights