AirHint found the following cheapest return flights from Lisbon (LIS) to Prague (PRG) in September 2025 (see full year).

Return flights

30 Sep - 07 Oct	easyJet
25 Sep - 30 Sep	easyJet
30 Sep - 06 Oct	Wizz Air Malta
24 Sep - 30 Sep	Wizz Air Malta
25 Sep - 02 Oct	easyJet
30 Sep - 02 Oct	easyJet
17 Sep - 24 Sep	Ryanair
24 Sep - 29 Sep	Wizz Air Malta
25 Sep - 29 Sep	easyJet
18 Sep - 22 Sep	Ryanair
24 Sep - 01 Oct	Wizz Air Malta
18 Sep - 02 Oct	Ryanair
30 Sep - 05 Oct	Wizz Air Malta
18 Sep - 20 Sep	Ryanair
18 Sep - 25 Sep	Ryanair
27 Sep - 04 Oct	easyJet
24 Sep - 26 Sep	Ryanair
24 Sep - 28 Sep	Wizz Air Malta
29 Sep - 05 Oct	Ryanair
29 Sep - 06 Oct	Ryanair

Also check the deals for one-way flights from Lisbon to Prague in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Prague

Cheap car rent in Prague

Cheapest return flights from Lisbon to Prague in September from 145€

Return flights