AirHint found the following cheapest return flights from London (LHR) to Santiago (SCL) in October 2025 (see full year).

Return flights

28 Oct - 11 Nov	Vueling Airlines
30 Oct - 13 Nov	Lufthansa
31 Oct - 14 Nov	Lufthansa
29 Oct - 04 Nov	Lufthansa
07 Oct - 14 Oct	TAP
30 Oct - 09 Nov	Lufthansa
29 Oct - 10 Nov	Lufthansa
23 Oct - 28 Oct	TAP
10 Oct - 19 Oct	Vueling Airlines
09 Oct - 25 Oct	Brussels Airlines
10 Oct - 20 Nov	Vueling Airlines
16 Oct - 23 Oct	TAP
25 Oct - 30 Oct	Vueling Airlines
13 Oct - 27 Oct	TAP
16 Oct - 26 Oct	TAP
14 Oct - 23 Oct	Avianca
20 Oct - 23 Oct	Avianca
21 Oct - 19 Nov	Avianca
30 Oct - 06 Nov	Avianca
21 Oct - 18 Nov	Avianca

Also check the deals for one-way flights from London to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from London to Santiago in October from 804€

Return flights