AirHint found the following cheapest return flights from London (LCY) to Santiago (SCL) in September 2025 (see full year).

Return flights

15 Sep - 14 Oct	KLM
11 Sep - 28 Sep	ITA Airways
18 Sep - 21 Oct	KLM
18 Sep - 13 Oct	KLM
14 Sep - 21 Sep	KLM
15 Sep - 19 Oct	Delta
16 Sep - 20 Oct	Delta
16 Sep - 19 Oct	Delta
11 Sep - 14 Sep	ITA Airways
18 Sep - 23 Sep	ITA Airways
22 Sep - 01 Oct	SWISS
11 Sep - 22 Sep	KLM
17 Sep - 24 Sep	KLM
16 Sep - 16 Oct	KLM
27 Sep - 01 Oct	Virgin Atlantic
15 Sep - 30 Sep	KLM
10 Sep - 26 Sep	ITA Airways
11 Sep - 30 Sep	KLM
10 Sep - 25 Sep	ITA Airways
16 Sep - 01 Oct	KLM

Also check the deals for one-way flights from London to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from London to Santiago in September from 1008€

Return flights