AirHint found the following cheapest return flights from London (LCY) to Santiago (SCL) in October 2025 (see full year).

Return flights

28 Oct - 10 Nov	ITA Airways
28 Oct - 04 Nov	SWISS
30 Oct - 10 Nov	SWISS
27 Oct - 10 Nov	SWISS
15 Oct - 22 Oct	ITA Airways
09 Oct - 22 Oct	ITA Airways
16 Oct - 23 Oct	ITA Airways
23 Oct - 30 Oct	ITA Airways
23 Oct - 02 Nov	ITA Airways
06 Oct - 19 Oct	Delta
08 Oct - 20 Oct	Delta
24 Oct - 08 Nov	Delta
24 Oct - 16 Nov	Delta
15 Oct - 29 Oct	ITA Airways
13 Oct - 27 Oct	ITA Airways
31 Oct - 09 Nov	KLM
02 Oct - 18 Oct	ITA Airways
01 Oct - 07 Oct	ITA Airways
29 Oct - 20 Nov	KLM
30 Oct - 25 Nov	British Airways

Also check the deals for one-way flights from London to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from London to Santiago in October from 972€

Return flights