AirHint found the following cheapest return flights from London (LCY) to Santiago (SCL) in October 2025 (see full year).

Return flights

29 Oct - 16 Nov	Delta
29 Oct - 10 Nov	KLM
29 Oct - 11 Nov	KLM
27 Oct - 03 Nov	KLM
29 Oct - 20 Nov	KLM
30 Oct - 10 Nov	KLM
30 Oct - 13 Nov	KLM
30 Oct - 12 Nov	KLM
30 Oct - 06 Nov	KLM
27 Oct - 10 Nov	KLM
26 Oct - 29 Oct	SWISS
24 Oct - 26 Oct	Air Dolomiti
24 Oct - 29 Oct	KLM
29 Oct - 31 Oct	KLM
24 Oct - 30 Oct	SWISS
25 Oct - 30 Oct	SWISS
25 Oct - 31 Oct	KLM
25 Oct - 28 Oct	SWISS

Also check the deals for one-way flights from London to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from London to Santiago in October from 1104€

Return flights