AirHint found the following cheapest return flights from New York (JFK) to Santiago (SCL) in October 2025 (see full year).

Return flights

29 Oct - 04 Nov	Frontier Airlines
26 Oct - 11 Nov	Frontier Airlines
26 Oct - 02 Nov	Frontier Airlines
20 Oct - 22 Oct	Avianca
25 Oct - 27 Oct	Frontier Airlines
26 Oct - 02 Nov	Delta	direct
23 Oct - 30 Oct	Frontier Airlines
23 Oct - 30 Oct	Delta	direct
20 Oct - 21 Oct	LATAM Airlines Group
20 Oct - 22 Oct	LATAM Airlines Group	direct
20 Oct - 21 Oct	Delta	direct

Also check the deals for one-way flights from New York to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from New York to Santiago in October from 446€

Return flights