AirHint found the following cheapest one-way flights from New York (JFK) to Santiago (SCL) in October 2025 (see full year).

One-Way flights

15 Oct	Frontier Airlines
22 Oct	Avianca
27 Oct	Avianca
28 Oct	Avianca
29 Oct	Avianca
27 Oct	LATAM Airlines Group	direct
30 Oct	Delta	direct
15 Oct	Delta	direct
29 Oct	LATAM Airlines Group	direct
24 Oct	Delta	direct

Also check the deals for return flights from New York to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from New York to Santiago in October from 201€

One-Way flights