AirHint found the following cheapest return flights from Istanbul (IST) to Madrid (MAD) in December 2025 (see full year).

Return flights

07 Dec - 09 Dec	AJet
06 Dec - 09 Dec	AJet
15 Dec - 16 Dec	AJet
07 Dec - 16 Dec	AJet
13 Dec - 16 Dec	AJet
14 Dec - 16 Dec	AJet
24 Dec - 11 Jan	Pegasus Airlines
13 Dec - 31 Dec	AJet
13 Dec - 17 Dec	AJet
15 Dec - 17 Dec	AJet
07 Dec - 11 Dec	AJet
24 Dec - 27 Jan	Pegasus Airlines	direct
26 Dec - 12 Jan	Pegasus Airlines	direct
24 Dec - 12 Jan	Pegasus Airlines	direct
15 Dec - 02 Jan	AJet
31 Dec - 06 Jan	AJet
31 Dec - 08 Jan	AJet
22 Dec - 02 Jan	Pegasus Airlines
11 Dec - 14 Jan	AJet
19 Dec - 02 Jan	Pegasus Airlines

Also check the deals for one-way flights from Istanbul to Madrid in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Istanbul to Madrid in December from 98€

Return flights