AirHint found the following cheapest return flights from Iquique (IQQ) to Santiago (SCL) in December 2025 (see full year).

Return flights

06 Dec - 08 Dec	JetSmart	direct
06 Dec - 07 Dec	JetSmart	direct
06 Dec - 23 Dec	JetSmart	direct
26 Dec - 06 Jan	JetSmart
26 Dec - 12 Jan	JetSmart
12 Dec - 23 Dec	JetSmart	direct
26 Dec - 08 Jan	JetSmart
26 Dec - 09 Jan	JetSmart
26 Dec - 10 Jan	JetSmart
26 Dec - 13 Jan	JetSmart
26 Dec - 15 Jan	JetSmart
26 Dec - 16 Jan	JetSmart
26 Dec - 02 Jan	JetSmart
27 Dec - 06 Jan	JetSmart	direct
08 Dec - 23 Dec	JetSmart	direct

Also check the deals for one-way flights from Iquique to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Iquique to Santiago in December from 51€

Return flights