AirHint found the following cheapest return flights from Nis (INI) to Istanbul (IST) in December 2025 (see full year).

Return flights

13 Dec - 16 Dec	Air Serbia	direct
23 Dec - 27 Dec	Air Serbia	direct
16 Dec - 20 Dec	Air Serbia	direct
27 Dec - 30 Dec	Air Serbia	direct
23 Dec - 06 Jan	Air Serbia	direct
24 Dec - 27 Dec	Air Serbia
27 Dec - 02 Jan	Turkish Airlines
30 Dec - 03 Jan	Air Serbia	direct
30 Dec - 02 Jan	Air Serbia
22 Dec - 31 Dec	Ryanair
29 Dec - 05 Jan	Ryanair
17 Dec - 24 Dec	Air Serbia
21 Dec - 26 Dec	Air Serbia
30 Dec - 04 Jan	Air Serbia

Also check the deals for one-way flights from Nis to Istanbul in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Nis to Istanbul in December from 121€

Return flights