AirHint found the following cheapest return flights from Indianapolis (IND) to Milano (MXP) in September 2025 (see full year).

Return flights

10 Sep - 24 Sep	Spirit Airlines
26 Sep - 18 Oct	Spirit Airlines
09 Sep - 16 Sep	United
23 Sep - 30 Sep	United
25 Sep - 02 Oct	United
29 Sep - 06 Oct	United
15 Sep - 22 Sep	United
19 Sep - 26 Sep	United
19 Sep - 11 Oct	Spirit Airlines
21 Sep - 28 Sep	United
17 Sep - 24 Sep	United
13 Sep - 20 Sep	United
05 Sep - 12 Sep	United
11 Sep - 18 Sep	United

Also check the deals for one-way flights from Indianapolis to Milano in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Indianapolis to Milano in September from 544€

Return flights