AirHint found the following cheapest return flights from Indianapolis (IND) to Madrid (MAD) in September 2025 (see full year).

Return flights

30 Sep - 07 Oct	Iberia
24 Sep - 01 Oct	Iberia
16 Sep - 23 Sep	Spirit Airlines
22 Sep - 29 Sep	Iberia
18 Sep - 25 Sep	Iberia
28 Sep - 05 Oct	Iberia
26 Sep - 03 Oct	Iberia
14 Sep - 21 Sep	United
20 Sep - 27 Sep	United
10 Sep - 17 Sep	Iberia
08 Sep - 15 Sep	Iberia
12 Sep - 19 Sep	Iberia
06 Sep - 13 Sep	United

Also check the deals for one-way flights from Indianapolis to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Indianapolis to Madrid in September from 501€

Return flights