AirHint found the following cheapest return flights from Houston (HOU) to Panama City (PTY) in September 2025 (see full year).

Return flights

25 Sep - 10 Oct	Spirit Airlines
19 Sep - 02 Oct	Spirit Airlines
18 Sep - 22 Sep	Spirit Airlines
20 Sep - 02 Oct	Spirit Airlines
20 Sep - 27 Sep	Spirit Airlines
19 Sep - 22 Sep	Spirit Airlines
17 Sep - 19 Sep	Spirit Airlines
25 Sep - 28 Sep	Spirit Airlines
23 Sep - 21 Oct	United	direct
23 Sep - 14 Oct	United	direct
25 Sep - 10 Oct	United	direct
23 Sep - 30 Sep	United	direct
25 Sep - 28 Sep	Copa	direct
19 Sep - 22 Sep	Copa	direct
18 Sep - 22 Sep	Copa	direct
20 Sep - 27 Sep	Copa	direct
19 Sep - 02 Oct	Copa	direct
20 Sep - 02 Oct	Copa	direct

Also check the deals for one-way flights from Houston to Panama City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Houston to Panama City in September from 422€

Return flights