AirHint found the following cheapest return flights from Houston (HOU) to Panama City (PTY) in September 2025 (see full year).

Return flights

24 Sep - 27 Sep	Spirit Airlines
24 Sep - 28 Sep	Spirit Airlines
11 Sep - 15 Sep	Spirit Airlines
01 Sep - 11 Sep	Spirit Airlines
18 Sep - 27 Sep	Spirit Airlines
23 Sep - 30 Sep	Spirit Airlines
07 Sep - 09 Sep	Spirit Airlines
13 Sep - 27 Sep	Spirit Airlines
11 Sep - 14 Sep	Spirit Airlines
28 Sep - 05 Oct	Spirit Airlines
23 Sep - 30 Sep	United	direct
23 Sep - 21 Oct	United	direct
23 Sep - 14 Oct	United	direct
28 Sep - 05 Oct	United	direct

Also check the deals for one-way flights from Houston to Panama City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Houston to Panama City in September from 351€

Return flights