AirHint found the following cheapest return flights from Houston (HOU) to Panama City (PTY) in May 2026 (see full year).

Return flights

14 May - 21 May	Frontier Airlines
15 May - 22 May	Frontier Airlines
12 May - 22 May	Spirit Airlines
20 May - 27 May	Spirit Airlines
18 May - 25 May	Frontier Airlines
17 May - 24 May	Frontier Airlines
26 May - 31 May	Spirit Airlines
22 May - 28 May	Avianca
21 May - 24 May	Avianca
14 May - 21 May	United	direct

Also check the deals for one-way flights from Houston to Panama City in May.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Houston to Panama City in May from 379€

Return flights