AirHint found the following cheapest return flights from Houston (HOU) to Panama City (PTY) in October 2025 (see full year).

Return flights

30 Oct - 06 Nov	Spirit Airlines
24 Oct - 27 Oct	Spirit Airlines
31 Oct - 07 Nov	Frontier Airlines
23 Oct - 27 Oct	Spirit Airlines
07 Oct - 10 Oct	Spirit Airlines
13 Oct - 16 Oct	Frontier Airlines
31 Oct - 03 Nov	Frontier Airlines
10 Oct - 13 Oct	Spirit Airlines
30 Oct - 06 Nov	United	direct
31 Oct - 07 Nov	United	direct
24 Oct - 27 Oct	Copa	direct
23 Oct - 27 Oct	Copa	direct
10 Oct - 13 Oct	United	direct
31 Oct - 03 Nov	United	direct
01 Oct - 29 Oct	United	direct
07 Oct - 10 Oct	Copa	direct

Also check the deals for one-way flights from Houston to Panama City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Houston to Panama City in October from 323€

Return flights