AirHint found the following cheapest return flights from Houston (HOU) to Istanbul (IST) in May 2026 (see full year).

Return flights

06 May - 09 Jun	Spirit Airlines
01 May - 22 May	Frontier Airlines
05 May - 09 Jun	Spirit Airlines
17 May - 24 May	Austrian Airlines
06 May - 17 May	KLM
14 May - 21 May	Austrian Airlines
13 May - 20 May	Austrian Airlines
12 May - 26 May	KLM
09 May - 23 May	KLM
18 May - 25 May	Frontier Airlines
18 May - 30 May	Brussels Airlines
15 May - 22 May	KLM
06 May - 09 Jun	Turkish Airlines	direct
05 May - 09 Jun	Turkish Airlines	direct
29 May - 25 Jun	Spirit Airlines

Also check the deals for one-way flights from Houston to Istanbul in May.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Houston to Istanbul in May from 597€

Return flights