AirHint found the following cheapest return flights from Guayaquil (GYE) to Santa Cruz (VVI) in December 2025 (see full year).
Return flights
| 25 Dec - 31 Jan | Avianca | ||
| 19 Dec - 22 Jan | Avianca |
Also check the deals for one-way flights from Guayaquil to Santa Cruz in December.
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