AirHint found the following cheapest return flights from Guayaquil (GYE) to Santa Cruz (VVI) in October 2025 (see full year).
Return flights
| 17 Oct - 24 Oct | Avianca | ||
| 18 Oct - 25 Oct | Avianca | ||
| 24 Oct - 10 Nov | LATAM Airlines Group |
Also check the deals for one-way flights from Guayaquil to Santa Cruz in October.
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