AirHint found the following cheapest return flights from Guayaquil (GYE) to Panama City (PTY) in December 2025 (see full year).

Return flights

24 Dec - 27 Dec	Avianca
09 Dec - 12 Dec	Avianca
08 Dec - 11 Dec	Avianca
02 Dec - 05 Dec	Avianca
04 Dec - 11 Dec	Avianca
03 Dec - 07 Dec	Avianca
06 Dec - 13 Dec	Avianca
06 Dec - 10 Dec	Avianca
04 Dec - 07 Dec	Avianca
03 Dec - 10 Dec	Avianca
31 Dec - 05 Jan	Avianca
31 Dec - 05 Jan	Copa	direct
25 Dec - 03 Jan	Avianca
28 Dec - 04 Jan	Avianca
25 Dec - 03 Jan	Copa	direct
26 Dec - 03 Jan	Copa	direct
30 Dec - 03 Jan	Copa	direct
29 Dec - 02 Jan	Copa	direct
29 Dec - 04 Jan	Copa	direct
28 Dec - 04 Jan	Copa	direct

Also check the deals for one-way flights from Guayaquil to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guayaquil to Panama City in December from 292€

Return flights