AirHint found the following cheapest return flights from Guayaquil (GYE) to Panama City (PTY) in December 2025 (see full year).

Return flights

26 Dec - 29 Dec	Avianca
25 Dec - 28 Dec	Avianca
23 Dec - 30 Dec	Avianca
26 Dec - 30 Dec	Avianca
23 Dec - 27 Dec	Avianca
23 Dec - 25 Dec	Avianca
20 Dec - 22 Dec	Avianca
31 Dec - 04 Jan	Avianca
30 Dec - 04 Jan	Avianca
20 Dec - 22 Dec	Copa	direct
31 Dec - 05 Jan	Avianca
26 Dec - 29 Dec	Copa	direct
25 Dec - 28 Dec	Copa	direct
29 Dec - 04 Jan	Avianca
30 Dec - 02 Jan	Avianca
27 Dec - 04 Jan	Copa	direct
30 Dec - 02 Jan	Copa	direct
31 Dec - 04 Jan	Copa	direct
29 Dec - 04 Jan	Copa	direct
30 Dec - 04 Jan	Copa	direct

Also check the deals for one-way flights from Guayaquil to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guayaquil to Panama City in December from 289€

Return flights