AirHint found the following cheapest return flights from Guatemala City (GUA) to Madrid (MAD) in October 2025 (see full year).

Return flights

08 Oct - 20 Oct	Spirit Airlines
17 Oct - 24 Oct	Spirit Airlines
06 Oct - 20 Oct	Spirit Airlines
08 Oct - 16 Oct	Spirit Airlines
01 Oct - 19 Oct	Spirit Airlines
06 Oct - 13 Oct	Spirit Airlines
20 Oct - 11 Nov	Spirit Airlines
01 Oct - 15 Oct	Spirit Airlines
15 Oct - 29 Oct	Spirit Airlines
13 Oct - 25 Oct	Volaris El Salvador
18 Oct - 25 Oct	Spirit Airlines
21 Oct - 08 Nov	Spirit Airlines
21 Oct - 04 Nov	Aeromexico
21 Oct - 05 Nov	Aeromexico
26 Oct - 06 Nov	Avianca
24 Oct - 15 Nov	Avianca
21 Oct - 06 Nov	Spirit Airlines
30 Oct - 05 Nov	Aeromexico
13 Oct - 05 Nov	Avianca
27 Oct - 04 Nov	Spirit Airlines

Also check the deals for one-way flights from Guatemala City to Madrid in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guatemala City to Madrid in October from $642

Return flights