AirHint found the following cheapest return flights from Sao Paulo (GRU) to Santiago (SCL) in September 2025 (see full year).

Return flights

27 Sep - 28 Sep	JetSmart	direct
09 Sep - 27 Sep	JetSmart	direct
07 Sep - 27 Sep	JetSmart	direct
26 Sep - 27 Sep	JetSmart	direct
10 Sep - 28 Sep	JetSmart	direct
06 Sep - 27 Sep	JetSmart	direct
10 Sep - 27 Sep	JetSmart	direct
18 Sep - 27 Sep	JetSmart	direct
26 Sep - 28 Sep	JetSmart	direct
08 Sep - 28 Sep	JetSmart	direct
27 Sep - 01 Oct	JetSmart
27 Sep - 05 Oct	JetSmart
27 Sep - 04 Oct	JetSmart
27 Sep - 07 Oct	JetSmart
29 Sep - 02 Oct	JetSmart
30 Sep - 07 Oct	JetSmart
26 Sep - 02 Oct	JetSmart
25 Sep - 04 Oct	JetSmart
30 Sep - 08 Oct	JetSmart
29 Sep - 04 Oct	JetSmart

Also check the deals for one-way flights from Sao Paulo to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Sao Paulo to Santiago in September from 153€

Return flights