AirHint found the following cheapest one-way flights from Sao Paulo (GRU) to Santiago (SCL) in September 2025 (see full year).

One-Way flights

27 Sep	JetSmart	direct
07 Sep	JetSmart	direct
02 Sep	JetSmart	direct
10 Sep	JetSmart	direct
05 Sep	JetSmart	direct
30 Sep	JetSmart	direct
09 Sep	JetSmart	direct
03 Sep	JetSmart	direct
26 Sep	JetSmart	direct
06 Sep	JetSmart	direct

Also check the deals for return flights from Sao Paulo to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Sao Paulo to Santiago in September from 66€

One-Way flights