AirHint found the following cheapest return flights from Frankfurt (FRA) to Santiago (SCL) in December 2025 (see full year).

Return flights

01 Dec - 08 Dec	LATAM Airlines Group
02 Dec - 28 Dec	Delta
10 Dec - 22 Dec	Delta
10 Dec - 24 Jan	Delta
05 Dec - 09 Dec	Delta
30 Dec - 21 Jan	Air Canada
31 Dec - 22 Jan	Air Canada
10 Dec - 14 Jan	Delta
29 Dec - 29 Jan	Air Canada
29 Dec - 20 Jan	Air Canada
29 Dec - 27 Jan	Air Canada
29 Dec - 28 Jan	Air Canada
01 Dec - 15 Dec	LATAM Airlines Group
01 Dec - 10 Dec	LATAM Airlines Group
01 Dec - 28 Dec	Delta
08 Dec - 30 Dec	Delta
02 Dec - 13 Dec	LATAM Airlines Group
01 Dec - 05 Dec	Ryanair
31 Dec - 14 Jan	Delta
20 Dec - 16 Jan	LATAM Airlines Group

Also check the deals for one-way flights from Frankfurt to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Frankfurt to Santiago in December from 712€

Return flights