AirHint found the following cheapest return flights from Frankfurt (FRA) to Santiago (SCL) in October 2025 (see full year).

Return flights

29 Oct - 26 Nov	Air Canada
01 Oct - 20 Oct	Delta
08 Oct - 17 Oct	Delta
15 Oct - 06 Nov	Delta
16 Oct - 06 Nov	Delta
30 Oct - 23 Nov	Delta
30 Oct - 10 Nov	Delta
31 Oct - 16 Nov	Delta
27 Oct - 17 Nov	Delta
16 Oct - 07 Nov	Delta
25 Oct - 09 Nov	Delta
02 Oct - 09 Oct	Delta
02 Oct - 05 Oct	Delta
06 Oct - 25 Oct	Delta
09 Oct - 16 Oct	Delta
10 Oct - 24 Oct	Delta
22 Oct - 27 Oct	LATAM Airlines Group
04 Oct - 24 Oct	LATAM Airlines Group
04 Oct - 25 Oct	LATAM Airlines Group
04 Oct - 08 Nov	Delta

Also check the deals for one-way flights from Frankfurt to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Frankfurt to Santiago in October from 759€

Return flights