AirHint found the following cheapest return flights from Frankfurt (FRA) to Santiago (SCL) in October 2025 (see full year).

Return flights

26 Oct - 23 Nov	American Airlines
14 Oct - 22 Oct	Delta
15 Oct - 28 Oct	Delta
14 Oct - 21 Oct	Delta
14 Oct - 27 Oct	Delta
29 Oct - 12 Nov	Delta
29 Oct - 17 Nov	Delta
23 Oct - 10 Nov	Delta
29 Oct - 16 Nov	Delta
23 Oct - 26 Nov	Delta
28 Oct - 14 Nov	Delta
28 Oct - 11 Nov	Delta
22 Oct - 17 Nov	Delta
22 Oct - 29 Oct	Delta
25 Oct - 11 Nov	United
20 Oct - 30 Oct	LATAM Airlines Group
15 Oct - 20 Oct	Delta
18 Oct - 20 Oct	Ryanair
19 Oct - 31 Oct	TAP
17 Oct - 26 Oct	Ryanair

Also check the deals for one-way flights from Frankfurt to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Frankfurt to Santiago in October from 780€

Return flights