AirHint found the following cheapest return flights from Frankfurt (FRA) to Panama City (PTY) in September 2025 (see full year).

Return flights

17 Sep - 29 Sep	Condor	direct
21 Sep - 29 Sep	Condor	direct
14 Sep - 25 Sep	Condor	direct
03 Sep - 18 Sep	Condor	direct
28 Sep - 09 Oct	Condor	direct
24 Sep - 09 Oct	Condor	direct
21 Sep - 11 Oct	KLM
13 Sep - 11 Oct	KLM
25 Sep - 06 Oct	Air France
27 Sep - 11 Oct	Air France
30 Sep - 09 Oct	Air France
10 Sep - 15 Sep	Condor	direct
21 Sep - 02 Oct	Condor	direct
18 Sep - 25 Sep	Air Europa
24 Sep - 10 Oct	KLM
14 Sep - 02 Oct	Air France
14 Sep - 22 Sep	Condor	direct
12 Sep - 21 Sep	KLM
20 Sep - 28 Sep	Air France
07 Sep - 15 Sep	Condor	direct

Also check the deals for one-way flights from Frankfurt to Panama City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Frankfurt to Panama City in September from 472€

Return flights