AirHint found the following cheapest return flights from Frankfurt (FRA) to Panama City (PTY) in September 2025 (see full year).

Return flights

15 Sep - 24 Sep	Air Europa
17 Sep - 24 Sep	Air Europa
07 Sep - 06 Oct	Condor	direct
03 Sep - 21 Oct	KLM
21 Sep - 11 Oct	Air France
13 Sep - 11 Oct	Air France
16 Sep - 08 Oct	KLM
15 Sep - 29 Sep	KLM
17 Sep - 29 Sep	KLM
03 Sep - 15 Sep	Condor	direct
03 Sep - 25 Sep	Condor	direct
10 Sep - 25 Sep	Condor	direct
03 Sep - 18 Sep	Condor	direct
07 Sep - 22 Sep	Condor	direct
27 Sep - 06 Oct	Air France
13 Sep - 27 Sep	Air France

Also check the deals for one-way flights from Frankfurt to Panama City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Panama City

Cheap car rent in Panama City

Cheapest return flights from Frankfurt to Panama City in September from 567€

Return flights