AirHint found the following cheapest return flights from Frankfurt (FRA) to Panama City (PTY) in December 2025 (see full year).

Return flights

01 Dec - 15 Dec	Condor	direct
08 Dec - 15 Dec	Condor	direct
31 Dec - 13 Jan	United
01 Dec - 17 Dec	Turkish Airlines
01 Dec - 22 Dec	Turkish Airlines
02 Dec - 16 Dec	Air France
29 Dec - 12 Jan	Delta
30 Dec - 12 Jan	Turkish Airlines
03 Dec - 14 Jan	Delta
26 Dec - 17 Jan	United
26 Dec - 16 Jan	United
01 Dec - 22 Dec	Condor	direct
15 Dec - 29 Dec	Air Europa
17 Dec - 13 Jan	Turkish Airlines
02 Dec - 04 Jan	Turkish Airlines
25 Dec - 01 Jan	Turkish Airlines
29 Dec - 15 Jan	Condor	direct
15 Dec - 29 Dec	Condor	direct
18 Dec - 30 Dec	Air France
18 Dec - 29 Dec	Air France

Also check the deals for one-way flights from Frankfurt to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Frankfurt to Panama City in December from 650€

Return flights