AirHint found the following cheapest return flights from Frankfurt (FRA) to Panama City (PTY) in December 2025 (see full year).

Return flights

01 Dec - 08 Dec	Condor	direct
27 Dec - 24 Jan	United
27 Dec - 14 Jan	United
02 Dec - 18 Dec	KLM
01 Dec - 14 Dec	KLM
15 Dec - 18 Dec	Condor	direct
29 Dec - 15 Jan	Turkish Airlines
06 Dec - 03 Jan	Turkish Airlines
29 Dec - 05 Jan	Turkish Airlines
08 Dec - 29 Dec	United
29 Dec - 12 Jan	Turkish Airlines
26 Dec - 18 Jan	Turkish Airlines
27 Dec - 03 Jan	Turkish Airlines
28 Dec - 06 Jan	United
25 Dec - 15 Jan	Condor	direct
18 Dec - 30 Dec	United
18 Dec - 31 Dec	United
15 Dec - 19 Dec	United
17 Dec - 29 Dec	United

Also check the deals for one-way flights from Frankfurt to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Frankfurt to Panama City in December from 650€

Return flights