AirHint found the following cheapest return flights from Frankfurt (FRA) to Panama City (PTY) in October 2025 (see full year).

Return flights

26 Oct - 30 Oct	KLM
01 Oct - 09 Oct	Condor	direct
01 Oct - 05 Oct	Air France
01 Oct - 15 Oct	Air France
01 Oct - 23 Oct	Air France
05 Oct - 09 Oct	Condor	direct
05 Oct - 20 Oct	Condor	direct
05 Oct - 16 Oct	Air France
01 Oct - 23 Oct	Condor	direct
27 Oct - 09 Nov	Air Europa
22 Oct - 13 Nov	Air Europa
13 Oct - 20 Oct	Air France
01 Oct - 26 Nov	Air France
29 Oct - 06 Nov	Air Europa
22 Oct - 13 Nov	Condor	direct
30 Oct - 07 Nov	Air Europa
30 Oct - 06 Nov	United
30 Oct - 22 Nov	United
29 Oct - 06 Nov	Condor	direct
22 Oct - 17 Nov	Delta

Also check the deals for one-way flights from Frankfurt to Panama City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Frankfurt to Panama City in October from 582€

Return flights