AirHint found the following cheapest return flights from Frankfurt (FRA) to Rio Negro (MDE) in October 2025 (see full year).

Return flights

22 Oct - 29 Oct	Ryanair
25 Oct - 13 Nov	Air Europa
25 Oct - 11 Nov	Air Europa
25 Oct - 08 Nov	Air Europa
02 Oct - 06 Nov	Ryanair
08 Oct - 15 Oct	Ryanair
26 Oct - 14 Nov	Air Europa
07 Oct - 20 Oct	Air Europa
23 Oct - 08 Nov	Ryanair
23 Oct - 01 Nov	Ryanair
04 Oct - 18 Oct	Ryanair
18 Oct - 16 Nov	Ryanair
07 Oct - 27 Oct	Avianca
30 Oct - 19 Nov	Air Europa
16 Oct - 26 Oct	Ryanair
26 Oct - 11 Nov	Avianca
01 Oct - 24 Oct	TAP
10 Oct - 24 Oct	TAP
10 Oct - 31 Oct	TAP

Also check the deals for one-way flights from Frankfurt to Rio Negro in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Frankfurt to Rio Negro in October from 631€

Return flights