AirHint found the following cheapest return flights from Rome (FCO) to Panama City (PTY) in December 2025 (see full year).

Return flights

19 Dec - 28 Dec	Turkish Airlines
05 Dec - 26 Jan	United
01 Dec - 01 Dec	Turkish Airlines
13 Dec - 30 Dec	Iberia
28 Dec - 30 Jan	Vueling Airlines
31 Dec - 31 Dec	Turkish Airlines
31 Dec - 12 Jan	Iberia
26 Dec - 12 Jan	Vueling Airlines
29 Dec - 12 Jan	Delta
19 Dec - 30 Dec	Air Europa
29 Dec - 05 Jan	Iberia
27 Dec - 06 Jan	Air France
24 Dec - 05 Jan	Iberia
25 Dec - 03 Jan	Air Europa
19 Dec - 02 Jan	Turkish Airlines

Also check the deals for one-way flights from Rome to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Panama City in December from 567€

Return flights