AirHint found the following cheapest return flights from Rome (FCO) to Panama City (PTY) in December 2025 (see full year).

Return flights

02 Dec - 27 Dec	Turkish Airlines
09 Dec - 14 Dec	Air Europa
02 Dec - 26 Dec	Air France
30 Dec - 30 Jan	ITA Airways
30 Dec - 29 Jan	ITA Airways
21 Dec - 27 Dec	Turkish Airlines
24 Dec - 28 Dec	ITA Airways
24 Dec - 27 Dec	Iberia
15 Dec - 11 Jan	United
20 Dec - 30 Dec	Turkish Airlines
18 Dec - 30 Dec	United
22 Dec - 10 Jan	Turkish Airlines
20 Dec - 28 Dec	Air Europa
14 Dec - 03 Jan	Turkish Airlines
27 Dec - 10 Jan	Delta
25 Dec - 07 Jan	Delta
22 Dec - 02 Jan	Turkish Airlines
24 Dec - 03 Jan	Turkish Airlines
29 Dec - 07 Jan	Air Europa

Also check the deals for one-way flights from Rome to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Panama City in December from 569€

Return flights