AirHint found the following cheapest return flights from Rome (FCO) to Panama City (PTY) in October 2025 (see full year).

Return flights

08 Oct - 16 Oct	Condor
24 Oct - 12 Nov	Iberia
08 Oct - 15 Oct	KLM
31 Oct - 15 Nov	Turkish Airlines
21 Oct - 28 Oct	Turkish Airlines
31 Oct - 10 Nov	Turkish Airlines
06 Oct - 17 Nov	Iberia
24 Oct - 07 Nov	Turkish Airlines
11 Oct - 26 Oct	Turkish Airlines
28 Oct - 12 Nov	Turkish Airlines
31 Oct - 16 Nov	Turkish Airlines
06 Oct - 09 Oct	Iberia
29 Oct - 06 Nov	Turkish Airlines
27 Oct - 15 Nov	Turkish Airlines
24 Oct - 13 Nov	Iberia
18 Oct - 25 Oct	Turkish Airlines
10 Oct - 12 Oct	Wizz Air Malta
15 Oct - 31 Oct	Ryanair
05 Oct - 10 Oct	Air Europa
06 Oct - 10 Oct	Air Europa

Also check the deals for one-way flights from Rome to Panama City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Panama City in October from 377€

Return flights