AirHint found the following cheapest return flights from Rome (FCO) to Istanbul (IST) in May 2026 (see full year).

Return flights

05 May - 14 May	Lufthansa
07 May - 14 May	Lufthansa
20 May - 27 May	Lufthansa
01 May - 08 May	Lufthansa
04 May - 12 May	Lufthansa
30 May - 02 Jun	Lufthansa
06 May - 13 May	Lufthansa
19 May - 21 May	Turkish Airlines	direct
07 May - 14 May	Turkish Airlines	direct
20 May - 27 May	Turkish Airlines	direct
05 May - 14 May	Turkish Airlines	direct
30 May - 06 Jun	Turkish Airlines	direct

Also check the deals for one-way flights from Rome to Istanbul in May.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Istanbul in May from 227€

Return flights