AirHint found the following cheapest return flights from Newark (EWR) to Panama City (PTY) in October 2025 (see full year).

Return flights

18 Oct - 25 Oct	Spirit Airlines
01 Oct - 15 Oct	Spirit Airlines
21 Oct - 28 Oct	Spirit Airlines
21 Oct - 30 Oct	Spirit Airlines
24 Oct - 27 Oct	Spirit Airlines
01 Oct - 08 Oct	Spirit Airlines
24 Oct - 31 Oct	Spirit Airlines
30 Oct - 14 Nov	Spirit Airlines
06 Oct - 20 Oct	Spirit Airlines
17 Oct - 03 Nov	Spirit Airlines
06 Oct - 13 Oct	Spirit Airlines
17 Oct - 19 Oct	Spirit Airlines
17 Oct - 03 Nov	United	direct
30 Oct - 14 Nov	United	direct

Also check the deals for one-way flights from Newark to Panama City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Newark to Panama City in October from 358€

Return flights