AirHint found the following cheapest return flights from Duesseldorf (DUS) to Prague (PRG) in September 2025 (see full year).

Return flights

21 Sep - 26 Sep	Eurowings	direct
15 Sep - 17 Sep	easyJet
22 Sep - 25 Sep	easyJet
15 Sep - 18 Sep	easyJet
25 Sep - 02 Oct	easyJet
20 Sep - 25 Sep	easyJet
22 Sep - 30 Sep	easyJet
09 Sep - 13 Sep	Eurowings	direct
25 Sep - 30 Sep	easyJet
15 Sep - 22 Sep	easyJet
11 Sep - 15 Sep	easyJet
28 Sep - 02 Oct	Eurowings
28 Sep - 01 Oct	Eurowings	direct
28 Sep - 02 Oct	Eurowings	direct
25 Sep - 02 Oct	Eurowings	direct
28 Sep - 05 Oct	Austrian Airlines
28 Sep - 05 Oct	Eurowings	direct

Also check the deals for one-way flights from Duesseldorf to Prague in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Duesseldorf to Prague in September from 107€

Return flights