AirHint found the following cheapest return flights from Detroit (DTW) to Prague (PRG) in December 2025 (see full year).

Return flights

06 Dec - 11 Dec	Spirit Airlines
06 Dec - 10 Dec	Spirit Airlines
09 Dec - 16 Dec	Lufthansa
10 Dec - 17 Dec	Lufthansa
04 Dec - 11 Dec	Spirit Airlines
02 Dec - 09 Dec	Lufthansa
08 Dec - 15 Dec	Lufthansa
08 Dec - 22 Dec	Lufthansa
05 Dec - 11 Dec	Spirit Airlines
06 Dec - 24 Dec	Lufthansa
30 Dec - 24 Jan	Lufthansa

Also check the deals for one-way flights from Detroit to Prague in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Detroit to Prague in December from 404€

Return flights