AirHint found the following cheapest return flights from Detroit (DTW) to Istanbul (IST) in December 2025 (see full year).

Return flights

03 Dec - 24 Dec	Lufthansa
09 Dec - 25 Dec	Lufthansa
02 Dec - 09 Dec	Lufthansa
04 Dec - 11 Dec	Lufthansa
09 Dec - 12 Jan	KLM
25 Dec - 12 Jan	KLM
07 Dec - 11 Jan	Lufthansa
04 Dec - 20 Dec	Lufthansa
07 Dec - 27 Dec	KLM
05 Dec - 27 Dec	KLM
02 Dec - 27 Dec	KLM
04 Dec - 27 Dec	KLM
03 Dec - 27 Dec	KLM
24 Dec - 14 Jan	Lufthansa
24 Dec - 17 Jan	Lufthansa
23 Dec - 13 Jan	Air France
24 Dec - 12 Jan	Lufthansa
04 Dec - 01 Jan	Spirit Airlines
05 Dec - 04 Jan	Spirit Airlines
16 Dec - 04 Jan	Spirit Airlines

Also check the deals for one-way flights from Detroit to Istanbul in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Detroit to Istanbul in December from 446€

Return flights