AirHint found the following cheapest return flights from Detroit (DTW) to Istanbul (IST) in December 2025 (see full year).

Return flights

06 Dec - 09 Dec	Spirit Airlines
11 Dec - 10 Jan	Spirit Airlines
03 Dec - 12 Jan	KLM
14 Dec - 28 Dec	KLM
03 Dec - 27 Dec	KLM
12 Dec - 19 Dec	KLM
24 Dec - 17 Jan	KLM
14 Dec - 21 Dec	KLM
13 Dec - 20 Dec	Spirit Airlines
15 Dec - 23 Dec	Air France
06 Dec - 09 Dec	Turkish Airlines	direct
19 Dec - 28 Dec	KLM
20 Dec - 10 Jan	KLM
17 Dec - 01 Jan	Spirit Airlines
03 Dec - 27 Dec	Turkish Airlines	direct
03 Dec - 12 Jan	Turkish Airlines	direct
23 Dec - 05 Jan	Spirit Airlines
17 Dec - 02 Jan	Spirit Airlines
27 Dec - 01 Jan	KLM
27 Dec - 01 Jan	Turkish Airlines	direct

Also check the deals for one-way flights from Detroit to Istanbul in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Detroit to Istanbul in December from 504€

Return flights