AirHint found the following cheapest return flights from Detroit (DTW) to Guatemala City (GUA) in October 2025 (see full year).

Return flights

22 Oct - 01 Nov	Spirit Airlines
22 Oct - 06 Nov	Spirit Airlines
22 Oct - 12 Nov	Spirit Airlines
15 Oct - 01 Nov	Spirit Airlines
25 Oct - 01 Nov	Spirit Airlines
25 Oct - 12 Nov	Spirit Airlines
25 Oct - 06 Nov	Spirit Airlines
31 Oct - 01 Nov	Spirit Airlines
31 Oct - 12 Nov	Spirit Airlines
31 Oct - 06 Nov	Spirit Airlines

Also check the deals for one-way flights from Detroit to Guatemala City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Detroit to Guatemala City in October from 231€

Return flights